There is distant talks of an uncurable illness in some books in the archives. There are further talks of a cure for poison being some specific flowers found in a garden (re: the 3rd prompt on this log). A lot of it is speculation.

There's nothing mentioning any constructs. Perhaps people back then didn't know they were constructs? Or perhaps they didn't exist? There are mentions of snakes biting, but accounts range from "got bitten by a snake today :) that sucks" and "got bitten by a snake today! dying soon, here is my last will, i leave my estate to such and such".